Anticholinesterases/Succinylcholine
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process succinylcholine properly.
What might happen:
The effects of succinylcholine may last for a longer time.
What you should do about this interaction:
Succinylcholine is only used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Vickers MDA. The mismanagement of suxamethonium apnoea. Br J Anaesth 1963; 35(4):260-8.
2.Gissen AJ, Katz RL, Karis JH, Papper EM. Neuromuscular block in man during prolonged arterial infusion with succinylcholine. Anesthesiology 1966 May-Jun;27(3):242-9.
3.Miller RD, Stevens WC. Antagonism of succinylcholine paralysis in a patient with atypical pseudocholinesterase. Anesthesiology 1972 May; 36(5):511-3.
4.Baraka A. Potentiation of suxamethonium blockade by neostigmine in patients with atypical cholinesterase. Br J Anaesth 1975 Mar;47(3):416-8.
5.Bentz EW, Stoelting RK. Prolonged response to succinylcholine following pancuronium reversal with pyridostigmine. Anesthesiology 1976 Mar; 44(3):258-60.
6.Baraka A. Suxamethonium-neostigmine interaction in patients with normal or atypical cholinesterase. Br J Anaesth 1977 May;49(5):479-84.
7.Kopman AF, Strachovsky G, Lichtenstein L. Prolonged response to succinylcholine following physostigmine. Anesthesiology 1978 Aug; 49(2):142-3.
