Nilotinib; Pazopanib/Grapefruit Juice (mono deleted 01/03/2013)
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Medical warning:
Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.
How the interaction occurs:
Grapefruit juice may increase the amount of nilotinib or pazopanib your body absorbs.
What might happen:
When nilotinib and pazopanib are taken with grapefruit juice, the grapefruit juice may cause the nilotinib or pazopanib to build up in your body. This increased amount of medicine will have a greater effect of both desired and undesired effects.
What you should do about this interaction:
While you are taking this medicine, you should avoid eating grapefruit or drinking grapefruit juice. You may choose an alternative citrus beverage (such as orange juice). In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice you should discuss with your doctor the effects of grapefruit on the blood levels of this medicine. This interaction may occur at any time in your treatment with nilotinib or pazopanib if grapefruit or grapefruit juice is consumed.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Tasigna (nilotinib) US prescribing information. Novartis Pharmaceuticals Corporation December, 2012.
2.Tasigna (nilotinib) UK prescribing information. Novartis Pharmaceuticals Corporation May, 2008.
3.Votrient (pazopanib) US prescribing information. GlaxoSmithKline November, 2012.
