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Intelence oral

Etravirine/Grapefruit Juice Interaction

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.

Medical warning:

Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.

How the interaction occurs:

Etravirine is processed by enzymes in your intestine. Grapefruit juice contains compounds that slow down this process.

What might happen:

The amount of etravirine can increase in your blood, which may increase the risk of liver problems and other side effects.

What you should do about this interaction:

While you are taking this medicine, you should not eat grapefruit or drink grapefruit juice at any time. Do not use grapefruit juice to dilute your medicine. You may choose an alternative citrus beverage (such as orange juice). In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice, you should immediately discuss with doctor the effects of grapefruit on the blood levels of this medicine.Contact your healthcare professional (e.g., doctor or pharmacist) for more information. Let your doctor know right away if you develop nausea, vomiting, or stomach pain that gets worse, dose not go away, or changes; fever; yellowing of the eyes or skin; increased tiredness; and/or flu-like symptoms.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.

References:

1.Intelence (etravirine) US prescribing information. Tibotec, Inc. February, 2013.
2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.

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