Etravirine; Nevirapine/Rifampin; Rifapentine
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Rifampin and rifapentine may speed up how quickly your liver processes etravirine or nevirapine.
What might happen:
The amount of etravirine or nevirapine in your blood may decrease and it may not work as well against your HIV infection.
What you should do about this interaction:
Contact your healthcare professional (e.g. doctor or pharmacist) right away about taking these medicines together. Your doctor may want to change your antibiotic.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Intelence (etravirine) US prescribing information. Tibotec, Inc. February, 2013.
2.Viramune (nevirapine) Australian prescribing information. Boehringer Ingelheim Pty Ltd. October 24, 2003.
3.Viramune (nevirapine) UK summary of product characteristics. Boehringer Ingelheim Limited April, 2007.
4.Viramune (nevirapine) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. November, 2011.
5.Viramune (nevirapine) Canadian prescribing information. Boehringer Ingelheim 2002.
6.Ribera E, Pou L, Lopez RM, Crespo M, Falco V, Ocana I, Ruiz I, Pahissa A. Pharmacokinetic interaction between nevirapine and rifampicin in HIV-infected patients with tuberculosis. J Acquir Immune Defic Syndr 2001 Dec 15;28(5):450-3.
