Mycophenolate/Non-Calcium Containing Phosphate Binders
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Medicines such as aluminum hydroxide, magnesium hydroxide, lanthanum, and sevelamer may decrease the amount of mycophenolate your body absorbs.
What might happen:
The levels of mycophenolate in your blood may decrease and the drug may not be as effective.
What you should do about this interaction:
You should not take any medicine containing magnesium hydroxide and/or aluminum hydroxide, lanthanum, or sevelamer at the same time you take your mycophenolate. You should separate taking the two medicines by several hours. Notify your healthcare professional (e.g. doctor or pharmacist) if you notice any change in your condition.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.CellCept (mycophenolate mofetil) US prescribing information. Roche Pharmaceuticals June, 2012.
2.Myfortic (mycophenolate sodium) US prescribing information. Novartis Pharmaceuticals Corporation June, 2012.
3.Bullingham R, Shah J, Goldblum R, Schiff M. Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients. Br J Clin Pharmacol 1996 Jun;41(6):513-6.
4.Pieper AK, Buhle F, Bauer S, Mai I, Budde K, Haffner D, Neumayer HH, Querfeld U. The effect of sevelamer on the pharmacokinetics of cyclosporin A and mycophenolate mofetil after renal transplantation. Nephrol Dial Transplant 2004 Oct;19(10):2630-3.
