Tacrine/Fluvoxamine
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Fluvoxamine may slow down how quickly your liver processes tacrine.
What might happen:
The amount of tacrine in your blood may increase and cause more side effects than normal.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. If you experience dizziness, unsteadiness, clumsiness, nausea, vomiting, diarrhea, or loss of appetite, contact your doctor. It may be necessary to adjust the dose of your medicine or change you to a different medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Luvox (fluvoxamine maleate) US prescribing information. ANI Pharmaceuticals November, 2012.
2.Becquemont L, Ragueneau I, Le Bot MA, Riche C, Funck-Brentano C, Jaillon P. Influence of the CYP1A2 inhibitor fluvoxamine on tacrine pharmacokinetics in humans. Clin Pharmacol Ther 1997 Jun;61(6):619-27.
3.Larsen JT, Hansen LL, Spigset O, Brosen K. Fluvoxamine is a potent inhibitor of tacrine metabolism in vivo. Eur J Clin Pharmacol 1999 Jul; 55(5):375-82.
4.Becquemont L, Le Bot MA, Riche C, Beaune P. Influence of fluvoxamine on tacrine metabolism in vitro: potential implication for the hepatotoxicity in vivo. Fundam Clin Pharmacol 1996;10(2):156-7.
