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Tiazac Oral

Buspirone/Diltiazem; Verapamil

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Diltiazem and verapamil may slow down how quickly your body processes buspirone.

What might happen:

The amount of buspirone in your blood may increase and cause more side effects than normal, such as lightheadedness, dizziness, weakness, or sleepiness.

What you should do about this interaction:

Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dose of your buspirone.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Lamberg TS, Kivisto KT, Neuvonen PJ. Effects of verapamil and diltiazem on the pharmacokinetics and pharmacodynamics of buspirone. Clin Pharmacol Ther 1998 Jun;63(6):640-5.
2.Cardizem LA (diltiazem hcl extended release tablets) US prescribing information. BTA Pharmaceuticals, Inc. November, 2010.

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