Buprenorphine; Methadone; Morphine/Rifampin
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process buprenorphine, methadone, and morphine more quickly.
What might happen:
Your blood levels of buprenorphine, methadone, or morphine may decrease and they may not work as well. You may experience drug withdrawal symptoms.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. If your medicine does not seem to be working as well, contact your healthcare professionals. If you experience nausea, vomiting, stomach pain, diarrhea, irritability, sleep disturbances, or other symptoms, contact your healthcare professionals. Your doctor may want to adjust the dose of your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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