HMG-CoA Reductase Inhibitors/Selected Fibrates
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known.
What might happen:
You may experience an increased risk of severe muscle pain, flu-like symptoms, and sudden decrease in the amount of urine.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. This interaction may be worse if you currently have any type of kidney problem.You healthcare professionals may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
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2.Lopid (gemfibrozil) US prescribing information. Pfizer Pharmaceuticals, Ltd. September, 2010.
3.Mevacor (lovastatin) US prescribing information. Merck & Co., Inc. February, 2012.
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8.Zocor (simvastatin) US prescribing information. Merck & Co., Inc. October, 2011.
9.Vytorin (ezetimibe/simvastatin) US prescribing information. Merck/Schering-Plough Pharmaceuticals October, 2012.
10.Tricor (fenofibrate) US prescribing information. Abbott Laboratories February, 2013.
11.VHA Pharmacy Benefits Management-Strategic Healthcare Group and The Medical Advisory Panel. STATIN-FIBRATE REPORT: Focus on Safety. available at: http://www.pbm.va.gov/safety%20reports/87ry38statin-fibrate-final.pdf September, 2004.
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18.Martin PD, Dane AL, Schneck DW, Warwick MJ. An open-label, randomized, three-way crossover trial of the effects of coadministration of rosuvastatin and fenofibrate on the pharmacokinetic properties of rosuvastatin and fenofibric acid in healthy male volunteers. Clin Ther 2003 Feb;25(2):459-71.
19.Wierzbicki AS, Lumb PJ, Cheung J, Crook MA. Fenofibrate plus simvastatin therapy versus simvastatin plus cholestyramine therapy for familial hypercholesterolaemia. QJM 1997 Oct;90(10):631-4.
20.Livalo (pitavastatin) US prescribing information. Kowa Pharmaceuticals America, Inc. October, 2012.





