Skip to content
My WebMD Sign In, Sign Up

Acid Reducer (cimetidine) oral

Lidocaine/Cimetidine

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may process the lidocaine more slowly.

What might happen:

There may be an increase in the beneficial effects and the toxic effects of your lidocaine.

What you should do about this interaction:

Tell your doctor if you have any dizziness, drowsiness, blurred vision, lightheadedness, slow heart rate, mood changes, or ringing in your ears.Your doctor may need to adjust the dose of your lidocaine, or exchange the cimetidine for another medicine.Make sure that your doctor knows all of the medicines that you are taking. Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Feely J, Wilkinson GR, Wood AJ. Reduction of liver blood flow and propranolol metabolism by cimetidine. N Engl J Med 1981 Mar 19; 304(12):692-5.
2.Knapp AB, Maguire W, Keren G, Karmen A, Levitt B, Miura DS, Somberg JC. The cimetidine-lidocaine interaction. Ann Intern Med 1983 Feb;98(2):174-7.
3.Patterson JH, Foster J, Powell JR, Cross R, Wargin W, Clark JL. Influence of a continuous cimetidine infusion on lidocaine plasma concentrations in patients. J Clin Pharmacol 1985 Nov-Dec;25(8):607-9.
4.Feely J, Guy E. Lack of effect of ranitidine on the disposition of lignocaine. Br J Clin Pharmacol 1983 Mar;15(3):378-9.
5.Robson RA, Wing LM, Miners JO, Lillywhite KJ, Birkett DJ. The effect of ranitidine on the disposition of lignocaine. Br J Clin Pharmacol 1985 Aug; 20(2):170-3.
6.Jackson JE, Bentley JB, Glass SJ, Fukui T, Gandolfi AJ, Plachetka JR. Effects of histamine-2 receptor blockade on lidocaine kinetics. Clin Pharmacol Ther 1985 May;37(5):544-8.
7.Abernethy DR, Schwartz JB, Todd EL. Lack of interaction between verapamil and cimetidine. Clin Pharmacol Ther 1985 Sep;38(3):342-9.
8.Kishikawa K, Namiki A, Miyashita K, Saitoh K. Effects of famotidine and cimetidine on plasma levels of epidurally administered lignocaine. Anaesthesia 1990 Sep;45(9):719-21.

Be the first to share your experience with this drug.

Review this Treatment

Find a Drug:

by name or medical condition or shape/color (Pill Identifier)

(for example: aspirin)

(for example: diabetes)

Report Problems to the Food and Drug Administration
 
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Ask the pharmacist

Questions about medications? Get expert answers by video or live chat about allergies, pregnancy, sleep, and more.
See the Ask the Pharmacist event schedule.

Ask a Question

Popular Slideshows & Tools on WebMD

hands on abdomen
Can you catch one?
Woman sitting in front of UV lights
Is yours working?
woman using breath spray
What's causing yours?
womans hand on abdomen
Are you ready for baby?
MS Overview
Recognizing symptoms.
bowl of yogurt with heart shape
Eat for a healthy heart.
woman doing pushups
To help you get fit.
Colored x-ray of tooth decay
Know what to look for.
Woman sitting with child
Do you know the symptoms?
mosquito
Stings, bites, burns, and more.
Allentown, PA
Are you living in one?
Thyroid exam
See how much you know.

Women's Health Newsletter

Find out what women really need.

WebMD the app

Get trusted health information. Whenever. Wherever... with your iPhone, iPad or Android.

Find Out More

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.