Raltegravir/H2 Antagonists; Proton Pump Inhibitors
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
H2 antagonists and proton pump inhibitors decrease the amount of acid in your digestive tract. This may allow your body to absorb more raltegravir.
What might happen:
The amount of raltegravir in your blood may increase and cause more side effects than normal.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have any unusual side effects from your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Isentress (raltegravir) UK summary of product characteristics. Merck Sharp & Dohme Limited January 7, 2009.
2.Isentress (raltegravir) US prescribing information. Merck & CO., Inc. August, 2012.
3.Iwamoto M, Wenning LA, Nguyen BY, Teppler H, Moreau AR, Rhodes RR, Hanley WD, Jin B, Harvey CM, Breidinger SA, Azrolan N, Farmer Jr HF, Isaacs RD, Chodakewitz JA, Stone JA, Wagner JA. Effects of Omeprazole on Plasma Levels of Raltegravir. Clin Infect Dis 2009 Jan 1.