Skip to content
My WebMD Sign In, Sign Up

Rifater oral

Rifampin/Pyrazinamide

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Rifampin and pyrazinamide are used with two other medicines to treat tuberculosis (TB). They are also used together without other agents to prevent TB. When they are used together to prevent TB, they can damage your liver. Your risk of having liver damage from using these medicines together may be greater if you already have some liver problems, if you are taking other medicines that can damage your liver, if you developed liver damage while taking isoniazid (another medicine for TB), or if you are an alcoholic.

What might happen:

Your liver could be damaged. Severe liver damage could result in death.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know if you have any liver problems, all the medicines that you are taking (including over-the-counter medicines), if you had problems with your liver after taking isoniazid, or if you are an alcoholic.If your doctor determines that taking rifampin and pyrazinamide together is the best way to prevent you from developing TB, you will be monitored closely by your healthcare professionals. Your pharmacist may only give you a two-week supply of your medicines. Your doctor may check your blood every two weeks to see if the medicines have affected your liver before approving another two week supply of your medicines.Take your medicines exactly as prescribed. Keep all appointments with your doctor and for lab tests. If you have any abdominal pain, vomiting, or if notice that your skin or eyes are turning yellow, stop taking your rifampin and pyrazinamide and contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Anonymous. Update: Fatal and severe liver injuries associated with rifampin and pyrazinamide for latent tuberculosis infection, and revisions in American Thoracic Society/CDC recommendations--United States, 2001. MMWR Morb Mortal Wkly Rep 2001 Aug 31;50(34):733-5.
2.Anonymous. Update: adverse event data and revised American Thoracic Society/CDC recommendations against the use of rifampin and pyrazinamide for treatment of latent tuberculosis infection--United States, 2003. MMWR Morb Mortal Wkly Rep 2003 Aug 8;52(31):735-9.

Be the first to share your experience with this drug.

Review this Treatment

Find a Drug:

by name or medical condition or shape/color (Pill Identifier)

(for example: aspirin)

(for example: diabetes)

Report Problems to the Food and Drug Administration
 
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Ask the pharmacist

Questions about medications? Get expert answers by video or live chat about allergies, pregnancy, sleep, and more.
See the Ask the Pharmacist event schedule.

Ask a Question

Popular Slideshows & Tools on WebMD

hands on abdomen
Can you catch one?
Woman sitting in front of UV lights
Is yours working?
woman using breath spray
What's causing yours?
womans hand on abdomen
Are you ready for baby?
MS Overview
Recognizing symptoms.
bowl of yogurt with heart shape
Eat for a healthy heart.
woman doing pushups
To help you get fit.
Colored x-ray of tooth decay
Know what to look for.
Woman sitting with child
Do you know the symptoms?
mosquito
Stings, bites, burns, and more.
Allentown, PA
Are you living in one?
Thyroid exam
See how much you know.

Women's Health Newsletter

Find out what women really need.

WebMD the app

Get trusted health information. Whenever. Wherever... with your iPhone, iPad or Android.

Find Out More

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.