Triamterene; Amiloride/Selected NSAIDs
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known. When these two medicines are taken together, the nonsteroidal anti-inflammatory medicine may increase the effects of the water pill on your kidney.
What might happen:
This combination may increase the chance for kidney failure or may increase the potassium levels in your blood.
What you should do about this interaction:
Contact your healthcare professionals (e.g., doctor or pharmacist) as soon as possible about taking these two medicines together. If your doctor prescribes these medicines together, it may be necessary to check your kidney function and certain blood levels more often.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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13.Maxzide (triamterene/hydrochlorothiazide) US prescribing information. Lederle January, 2011.
14.Dyazide (triamterene/hydrochlorothiazide) US prescribing information. Glaxo SmithKline February, 2011.
15.Midamor (amiloride) US prescribing information. Merck & Co., Inc. November, 2002.
16.Moduretic (amiloride/hydrochlorothiazide) US prescribing information. Merck & Co., Inc. November, 2002.
17.Aldactazide (spironolactone/hydrochlorothiazide) US prescribing information. Pfizer June, 2013.
18.Aldactone (spironolactone) US prescribing information. Pfizer June, 2013.