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estradiol valerate-dienogest oral

Contraceptives/Xanthine Derivatives

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process theophylline properly.

What might happen:

Your blood levels of theophylline may increase and cause toxic effects.

What you should do about this interaction:

If you experience loss of appetite, nausea, vomiting, nervousness, agitation, headache, fast and/or irregular heartbeat, or seizures, contact your healthcare professionals (e.g. doctor or pharmacist). They may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Tornatore KM, Kanarkowski R, McCarthy TL, Gardner MJ, Yurchak AM, Jusko WJ. Effect of chronic oral contraceptive steroids on theophylline disposition. Eur J Clin Pharmacol 1982;23(2):129-34.
2.Roberts RK, Grice J, McGuffie C, Heilbronn L. Oral contraceptive steroids impair the elimination of theophylline. J Lab Clin Med 1983 Jun; 101(6):821-5.
3.Gardner MJ, Tornatore KM, Jusko WJ, Kanarkowski R. Effects of tobacco smoking and oral contraceptive use on theophylline disposition. Br J Clin Pharmacol 1983 Sep;16(3):271-80.
4.Jusko WJ, Gardner MJ, Mangione A, Schentag JJ, Koup JR, Vance JW. Factors affecting theophylline clearances: age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanol. J Pharm Sci 1979 Nov;68(11):1358-66.
5.Koren G, Chin TF, Correia J, Tesoro A, MacLeod SM. Theophylline pharmacokinetics in adolescent females following coadministration of oral contraceptives. Clin Invest Med 1985;8(3):222-6.
6.Pollock BG, Wylie M, Stack JA, Sorisio DA, Thompson DS, Kirshner MA, Folan MM, Condifer KA. Inhibition of caffeine metabolism by estrogen replacement therapy in postmenopausal women. J Clin Pharmacol 1999 Sep;39(9):936-40.
7.Balogh A, Klinger G, Henschel L, Borner A, Vollanth R, Kuhnz W. Influence of ethinylestradiol-containing combination oral contraceptives with gestodene or levonorgestrel on caffeine elimination. Eur J Clin Pharmacol 1995;48(2):161-6.
8.Meyer FP, Canzler E, Giers H, Walther H. Time course of inhibition of caffeine elimination in response to the oral depot contraceptive agent Deposiston. Hormonal contraceptives and caffeine elimination. Zentralbl Gynakol 1991;113(6):297-302.

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