Abatacept/Tumor Necrosis Factor (TNF) Blocking Agents
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines affect your immune system.
What might happen:
When these medicines are used together, your risk of developing infections, including serious infections, may increase.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want to change your medicine. Let your doctor know right away if you develop any signs of infection, including infections that are only in one place in your body (such as a open sore or cut) or in your whole body (such as the flu), of if you feel sick.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Orencia (abatacept) US prescribing information. Bristol-Myers Squibb Company January, 2012.
2.Humira (adalimumab) US prescribing information. Abbott Laboratories May, 2012.
3.Cimza (certolizumab pegol) US prescribing information. UCB, Inc. November, 2012.
4.Simponi (golimumab) US prescribing information. Centocor Ortho Biotech Inc. November, 2012.
5.Remicade (infliximab) US prescribing information. Janssen Biotech, Inc. March, 2013.
