Ruxolitinib/Grapefruit Juice
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Medical warning:
Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.
How the interaction occurs:
Grapefruit juice decreases the ability of your gut to process ruxolitinib.
What might happen:
The amount of ruxolitinib in your blood may increase and cause more or more severe side effects than expected.
What you should do about this interaction:
While you are taking this medicine, you should avoid eating grapefruit or drinking grapefruit juice. You may choose an alternative citrus beverage (such as orange juice).In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice, you should immediately discuss with your doctor the effects of grapefruit on the blood levels of this medicine. Let your doctor know right away if you develop any unusual bleeding, bruising, fatigue, shortness of breath, chills, aches, fever, nausea, vomiting, weakness, or a painful rash/blisters.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.Reference:1.Jakafi (ruxolitinib) US prescribing information. Incyte Corporation November, 2011.
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