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Drugs & Medications A-Z

FIRST-Omeprazole Oral

Back to Drug Overview

Cilostazol/Esomeprazole; Omeprazole

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process cilostazol properly.

What might happen:

Your blood levels of cilostazol may increase and cause harmful effects.

What you should do about this interaction:

Contact your doctor if you experience headache; diarrhea; dizziness; or bloating or swelling of the ankles, feet, or hands. The dose of your medicines may need adjusting.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Pletal (cilostazol) US prescribing information. Otsuka America Pharmaceutical, Inc. November, 2007.
2.Nexium (esomeprazole magnesium) US prescribing information. AstraZeneca Pharmaceuticals LP October, 2012.
3.Prilosec (omeprazole) US prescribing information. AstraZeneca Pharmaceuticals LP October, 2012.
4.Suri A, Bramer SL. Effect of omeprazole on the metabolism of cilostazol. Clin Pharmacokinet 1999;37 Suppl 2:53-9.

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