Guanfacine/Strong CYP3A4 Inhibitors
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your medicine may slow down how quickly your liver processes guanfacine.
What might happen:
Your blood levels of guanfacine may increase and cause more side effects than expected.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Contact your doctor if you experience fainting, low heart rate, low blood pressure, or excessive sleepiness.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Intuniv (guafacine) US prescribing information. Shire LLC August, 2013.
2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.
3.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2014..