Boceprevir/Strong CYP 3A4 Inducers
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampin, and St. John's wort may speed up how quickly your liver processes boceprevir.
What might happen:
The amount of boceprevir in your blood may decrease and it may not work as well.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together or if you have taken carbamazepine, dexamethasone, phenobarbital, phenytoin, rifampin, or St. John's wort in the previous two weeks, or if you stop taking St. John's wort. Your doctor may want to adjust your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Victrelis (boceprevir) US prescribing information. Schering Corporation February, 2013.