Atazanavir/Efavirenz
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Efavirenz may speed up how quickly your body processes atazanavir.
What might happen:
The amount of protease inhibitor in your blood may decrease and it may not work as well against your HIV infection.
What you should do about this interaction:
To prevent this interaction from occurring with atazanavir, your doctor may give you a low dose of ritonavir to taken with your medicines. If you are not taking ritonavir, discuss it with your healthcare professional (e.g. doctor or pharmacist).If you have any side effects from your medicine, let your healthcare professional know.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company January, 2013.
2.Reyataz (atazanavir sulfate) Australian product information. Bristol-Myers Squibb Pharmaceuticals January 8, 2004.
3.Sustiva (efavirenz) US prescribing information. Bristol-Myers Squibb Company August, 2012.
4.Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) US prescribing information. Gilead Sciences, Inc. June, 2012.
