Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Conivaptan may slow down how quickly your liver processes midazolam.
What might happen:
The amount of midazolam in your body may increase and cause more side effects than normal.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these two medications together.Contact your healthcare professional if you experience any difficulty breathing, excess drowsiness, confusion, or loss of coordination.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Vaprisol (conivaptan hydrochloride) US prescribing information. Astellas Pharma US, Inc. February, 2012.