Serotonin Reuptake Inhibitors/Linezolid
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines can affect blood pressure and behavior.
What might happen:
When these two medicines are taken together, you may develop a medical condition that may be life threatening.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.If you experience irritability, double vision, nausea, confusion, anxiety, fever, increased muscle stiffness, or loss of consciousness, contact your doctor as soon as possible.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Prozac (fluoxetine hydrochloride) US prescribing information. Eli Lilly and Company January, 2009.
2.Zoloft (sertraline) US prescribing information. Pfizer Inc. January, 2009.
3.Effexor (venlafaxine hydrochloride) US prescribing information. Wyeth Pharmaceuticals November, 2009.
4.Fluvoxamine maleate US prescribing information. BayPharma, Inc. February, 2009.
5.Serzone (nefazodone hydrochloride) US prescribing information. Bristol-Myers Squibb Company January, 2005.
6.Pexeva (paroxetine mesylate) US prescribing information. JDS Pharmaceuticals, LLC January, 2009.
7.Bernard L, Stern R, Lew D, Hoffmeyer P. Serotonin syndrome after concomitant treatment with linezolid and citalopram. Clin Infect Dis 2003 May 1;36(9):1197.
8.Wigen CL, Goetz MB. Serotonin syndrome and linezolid. Clin Infect Dis 2002 Jun 15;34(12):1651-2.
9.Hachem RY, Hicks K, Huen A, Raad I. Myelosuppression and serotonin syndrome associated with concurrent use of linezolid and selective serotonin reuptake inhibitors in bone marrow transplant recipients. Clin Infect Dis 2003 Jul 1;37(1):e8-11.
10.Lexapro (escitalpram oxalate) US prescribing information. Forest Pharmaceuticals Inc. January, 2009.
11.Celexa (citalopram hydrobromide) US prescribing information. Forest Laboratories Inc. January, 2009.
12.Cymbalta (duloxetine hydrochloride) US prescribing information. Eli Lilly and Company February, 2009.
13.Tahir N. Serotonin syndrome as a consequence of drug-resistant infections: an interaction between linezolid and citalopram. J Am Med Dir Assoc 2004 Mar-Apr;5(2):111-3.
14.Bergeron L, Boule M, Perreault S. Serotonin toxicity associated with concomitant use of linezolid. Ann Pharmacother 2005 May;39(5):956-61.
15.Thomas CR, Rosenberg M, Blythe V, Meyer WJ 3rd. Serotonin syndrome and linezolid. J Am Acad Child Adolesc Psychiatry 2004 Jul;43(7):790.
16.Morales N, Vermette H. Serotonin syndrome associated with linezolid treatment after discontinuation of fluoxetine. Psychosomatics 2005 May-Jun;46(3):274-5.
17.Lavery S, Ravi H, McDaniel WW, Pushkin YR. Linezolid and serotonin syndrome. Psychosomatics 2001 Sep-Oct;42(5):432-4.
18.Jones SL, Athan E, O'Brien D. Serotonin syndrome due to co-administration of linezolid and venlafaxine. J Antimicrob Chemother 2004 Jul; 54(1):289-90.
19.Clark DB, Andrus MR, Byrd DC. Drug interactions between linezolid and selective serotonin reuptake inhibitors: case report involving sertraline and review of the literature. Pharmacotherapy 2006 Feb;26(2):269-76.
