Cilostazol/Grapefruit Juice Interaction
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Important. Possible changes in your diet, medicine, or dosage should be discussed with your doctor or pharmacist.
How the interaction occurs:
Cilostazol is processed by enzymes in your intestine. Grapefruit juice contains compounds that slow down this process.
What might happen:
The level of this drug may increase in your blood. This might lead to adverse effects such as headache, palpitations, dizziness, diarrhea, swelling in legs or runny nose.
What you should do about this interaction:
While you are taking this medicine, you should avoid eating grapefruit or drinking grapefruit juice. You may choose an alternative citrus beverage (such as orange juice). In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice, you should immediately discuss with doctor the effects of grapefruit on the blood levels of this medicine. If you notice an increase in any side effect from your medicine such as headache, palpitations, or diarrhea, contact your doctor.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.Reference:1.Pletal (cilostazol) US prescribing information. Otsuka America, Inc. November, 2007.