This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
At first, rifampin may increase how much bosentan your body absorbs, but after a few days, rifampin may increase how quickly your liver processes bosentan.
What might happen:
At first, the amount of bosentan in your blood may increase and cause more side effects than normal; however, after a few days, the amount of bosentan in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to run tests to check your liver more often while you are taking rifampin. If you have any headaches, nausea, vomiting, fever, unusual tiredness, abdominal pain, or yellowing of the skin or whites of your eyes, contact your doctor. If you notice any change in your condition, contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.van Giersbergen PL, Treiber A, Schneiter R, Dietrich H, Dingemanse J. Inhibitory and inductive effects of rifampin on the pharmacokinetics of bosentan in healthy subjects. Clin Pharmacol Ther 2007 Mar;81(3):414-9.
2.Tracleer (bosentan) US prescribing information. Actelion Pharmaceuticals US, Inc. October, 2012.