Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When delavirdine or rilpivirine are taken at the same time as didanosine, your body absorbs less of each medicine.
What might happen:
The levels of HIV medicine in your blood may decrease, making your medicines less effective.
What you should do about this interaction:
You should not take didanosine at the same time that you take your delavirdine or rilpivirine. You should separate the times that you take delaviridine and didanosine by at least one hour. You should take didanosine no closer than 2 hours before rilpivirine or 4 hours after rilpivirine. If you have any questions about how to take your medicines, ask your pharmacist.If you have been taking these medicines at the same time, let your healthcare professionals (e.g. doctor or pharmacist) know. Your doctor may want to run some blood tests to see if your medicines are working properly.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Rescriptor (delavirdine mesylate) US prescribing information. Pharmacia & Upjohn Company August, 2012.
2.Videx (didanosine) US prescribing information. Bristol-Myers Squibb Company November, 2011.
3.Edurant (rilpivirine) US prescribing information. Tibotec Pharmaceuticals June, 2013.