Fosphenytoin/Selected QT Prolonging Agents
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of your medicines may affect your heart's rhythm.
What might happen:
Taking more than one medicine that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening.
What you should do about this interaction:
Let your healthcare professionals (e.g doctor or pharmacist) know right away that you are taking these medications together. Let your doctor know right away if you notice an irregular heartbeat or have dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Firdapse (amifampridine phosphate) UK summary of product characteristics. BioMarin Europe Limited February, 2010.
2.Vascor (bepridil hydrochloride) US prescribing information. Ortho-McNeil Pharmaceutical, Inc. March, 2000.
3.Prepulsid (cisapride) Australian prescribing information. Janssen-Cilag Pty Limited January 25, 2003.
4.Inapsine (droperidol) US prescribing information. Akorn, Inc. November, 2001.
5.Halfan (halofantrine hydrochloride) US prescribing information. SmithKline Beecham Pharmaceuticals October, 2001.
6.Orap (pimozide) US prescribing information. Gate Pharmaceuticals August, 2011.
7.Orlaam (levomethadyl acetate hydrochloride) US prescribing information. Roxane Laboratories, Inc. May, 2001.
8.Serdolect (sertindole) UK summary of product characteristics. Lundbeck Limited October 25, 1996.
9.Zagam (sparfloxacin) US prescribing information. Bertek Pharmaceuticals, Inc. February, 2003.
10.Thioridazine tablet, US prescribing information. Mylan Pharmaceuticals September, 2010.
11.Geodon (ziprasidone hydrochloride) US prescribing information. Pfizer Inc. December, 2010.
12.The University of Arizona Center for Education and Research of Therapeutics. Drugs with Risk of Torsades de Pointes and Drugs with Possible Risk of Torsades de Pointes. Available at:http://www.crediblemeds.org/. Updated March 14, 2013.
