Anticoagulants/Chloral Hydrate; Triclofos
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process your blood-thinning medicine properly.
What might happen:
You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, it may be necessary to check your bleeding times more often. The dose of your blood-thinner may need adjusting. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
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2.MacDonald MG, Robinson DS, Sylwester D, Jaffe JJ. The effects of phenobarbital, chloral betaine, and glutethimide administration on warfarin plasma levels and hypoprothrombinemic responese in man. Clin Pharmacol Ther 1969 Jan-Feb;10(1):80-4.
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5.Koch-Weser J, Sellers EM, Udall JA, Griner PF, Rickles FR. Chloral hydrate and warfarin therapy. Ann Intern Med 1971 Jul;75(1):141-2.
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9.Sellers EM, Lang M, Koch-Weser J, Colman RW. Enhancement of warfarin-induced hypoprothrombinemia by triclofos. Clin Pharmacol Ther 1972 Nov-Dec;13(6):911-5.
10.Orme M, Breckenridge A, Brooks RV. Interactions of benzodiazepines with warfarin. Br Med J 1972 Sep 9;3(827):611-4.
11.Anonymous. Chloral hydrate and oral anticoagulants. Lancet 1972 Mar 4; 1(7749):524.
12.Anonymous. Interaction between chloral hydrate and warfarin. A report from the Boston Collaborative Drug Surveillance Program, Boston Universtiy Medical Center. N Engl J Med 1972 Jan 13;286(2):53-5.
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14.Udall JA. Warfarin-chloral hydrate interaction. Pharmacological activity and clinical significance. Ann Intern Med 1974 Sep;81(3):341-4.
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