Digoxin/Selected Antacids; Sucralfate
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, sucralfate may prevent your body from absorbing digoxin properly.
What might happen:
Your blood levels of digoxin may decrease. This may decrease the beneficial effects of your digoxin.
What you should do about this interaction:
If you experience shortness of breath or a fast heartbeat, contact your doctor. It may be necessary to change the time you take each medicine or change you to a different medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Giesing DH, Lanman RC, Dimmitt DC, Runser DJ. Lack of effect of sucralfate on digoxin pharmacokinetics. Gastroenterology 1983 May;84(5 Part 2):1165.
2.Rey AM, Gums JG. Altered absorption of digoxin, sustained-release quinidine, and warfarin with sucralfate administration. DICP 1991 Jul-Aug; 25(7-8):745-6.
3.Brown DD, Juhl RP. Decreased bioavailability of digoxin due to antacids and kaolin-pectin. N Engl J Med 1976 Nov 4;295(19):1034-7.
4.McElnay JC, Harron DW, D'Arcy PF, Eagle MR. Interaction of digoxin with antacid constituents. Br Med J 1978 Jun 10;1(6126):1554.
5.Allen MD, Greenblatt DJ, Harmatz JS, Smith TW. Effect of magnesium--aluminum hydroxide and kaolin--pectin on absorption of digoxin from tablets and capsules. J Clin Pharmacol 1981 Jan;21(1):26-30.
