Selected Narcotics/Rasagiline; Selegiline
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is unknown.
What might happen:
You may experience weakness, fatigue, drowsiness, and extremely high fever. This reaction may be life threatening.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Rivers N, Horner B. Possible lethal reaction between Nardil and dextromethorphan. Can Med Assoc J 1970 Jul;103:85.
2.Sovner R, Wolfe J. Interaction between dextromethorphan and monoamine oxidase inhibitor therapy with isocarboxazid. N Engl J Med 1988 Dec 22; 319(25):1671.
3.Garbutt JC. Potentiation of propoxyphene by phenelzine. Am J Psychiatry 1987 Feb;144(2):251-2.
4.Evans-Prosser CD. The use of pethidine and morphine in the presence of monoamine oxidase inhibitors. Br J Anaesth 1968 Apr;40(4):279-82.
5.Carlsson A, Lindqvist M. Central and peripheral monoaminergic membrane-pump blockade by some addictive analgesics and antihistamines. J Pharm Pharmacol 1969 Jul;21(7):460-4.
6.Avinza (morphine extended-release capsules) US prescribing information. Ligand Pharmaceuticals Incorporated July, 2012.
7.Metharose (methadone hydrochloride) UK summary of product characteristics. Rosemone Pharmaceuticals Limited January 9, 2008.
8.Diskets Dispersible (methadone hydrochloride) US prescribing information. Cebert Pharmaceuticals, Inc. August, 2007.
9.Emsam (selegline) US prescribing information. Somerset February, 2008.
10.Zelapar (selegiline hydrochloride) US prescribing information. Valeant Pharmaceuticals North America May, 2007.
11.Azilect (rasagiline) US prescribing information. Teva Neurosciences Inc. December, 2009.
