Eplerenone/Moderate CYP3A4 Inhibitors
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines may slow down how quickly your liver processes eplerenone.
What might happen:
The amount of eplerenone in your blood may increase. This may cause your blood pressure to become too low or your potassium levels to become too high. Symptoms of low blood pressure include fainting or dizziness. Symptoms of a high potassium level include breathing difficulties, chest pain, slow or irregular heartbeat, confusion, or muscle weakness.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check your potassium level and your blood pressure more frequently while you are taking these medicines together. Let your healthcare professional know if you have any symptoms of low blood pressure or a high potassium level.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Inspra (eplerenone) US prescribing information. Pfizer, Inc. May, 2013.
2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.