Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Pramlintide slows down the movement of food through your stomach. Alpha glucosidase inhibitors such as acarbose and miglitol slow down the absorption of nutrients from the intestine.
What might happen:
You may develop low blood sugar. Symptoms of low blood sugar include chills, cold sweat, dizziness, drowsiness, shaking, rapid heartbeat, weakness, headache, fainting, tingling of the hands or feet, or hunger. Severe low blood sugar makes it hard to think clearly, drive a car, use heavy machinery, or do other risky activities where you could hurt yourself or others.
What you should do about this interaction:
Contact your healthcare professional (e.g. doctor or pharmacist) right away about using these medicines together. Your doctor may want you to check your blood sugar more often while taking them together.Carry a source of glucose (such as glucose tablets or gel, table sugar, honey, candy, orange juice, or non-diet soda) with you to quickly raise your blood sugar level if it is too low. Let your doctor know that you are experiencing low blood sugar.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Symlin (pramlintide acetate) US prescribing information. Amylin Pharmaceuticals Inc. March, 2005.