Acitretin/Methotrexate
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of this interaction is not known.
What might happen:
You may have an increased risk of developing serious liver problems. Signs of liver problems may include yellowing of the skin or eyes or abdominal pain.
What you should do about this interaction:
Talk to your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. Contact your doctor if you notice any yellowing of your skin or eyes, or if you have any abdominal pain.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Soriatane (acitretin) US prescribing information. Roche Pharmaceuticals October, 2007.
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