Lurasidone/Strong CYP3A4 Inducers
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your medicine may speed up how quickly your liver processes lurasidone.
What might happen:
The amount of lurasidone in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together if you have taken carbamazepine, enzalutamide, phenobarbital, phenytoin, rifampin, rifabutin, or St. John's wort in the previous two weeks. Let your doctor know if your symptoms get worse.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Latuda (lurasidone hydrochloride) US prescribing information. Sunovion Pharamceuticals, Inc. July, 2013.
2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.