This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Rifamycins speed up how quickly your liver processes tolvaptan.
What might happen:
The amount of tolvaptan in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you experience nausea; vomiting; headaches; confusion; lethargy; fatigue; appetite loss; restlessness/irritability; muscle weakness, spasms, or cramps; seizures; decreased consciousness; and/or coma.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.Reference:1.Samsca (tolvaptan) US prescribing information. Otsuka Pharmaceutical Co., Ltd. May, 2013.