Ketorolac/Probenecid
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may remove ketorolac more slowly.
What might happen:
Your blood levels of ketorolac may increase and cause toxic effects.
What you should do about this interaction:
If you experience coffee ground vomit, black or tarry stools, or other signs of bleeding, contact your doctor.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Runkel R, Mroszczak E, Chaplin M, Sevelius H, Segre E. Naproxen-probenecid interaction. Clin Pharmacol Ther 1978 Dec;24(6):706-13.
2.Upton RA, Williams RL, Buskin JN, Jones RM. Effects of probenecid on ketoprofen kinetics. Clin Pharmacol Ther 1982 Jun;31(6):705-12.
3.Sinclair H, Gibson T. Interaction between probenecid and indomethacin. Br J Rheumatol 1986 Aug;25(3):316-7.
4.Toradol (ketorolac tromethamine) US prescribing information. Roche Pharmaceuticals March, 2013.
