Skip to content
My WebMD Sign In, Sign Up

Dilantin-125 oral

Hydantoins/Select Neuromuscular Blocking Agents

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Phenytoin interferes with the action of the neuromuscular blocking agent.

What might happen:

There might be a decreased effectiveness of the neuromuscular blocking agent.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) knows that you are taking medicine for seizures.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicines before checking with them first.

References:

1.Chen J Kim YD Dubois M Kammerer W Macnamara TE. The increased requirement of pancuronium in neurosurgical patients receiving Dilantin chronically. Anesthesiology Sept 1983;59(3):A288.
2.Ornstein E, Matteo RS, Young WL, Diaz J. Resistance to metocurine-induced neuromuscular blockade in patients receiving phenytoin. Anesthesiology 1985 Sep;63(3):294-8.
3.Liberman BA, Norman P, Hardy BG. Pancuronium-phenytoin interaction: a case of decreased duration of neuromuscular blockade. Int J Clin Pharmacol Ther Toxicol 1988 Aug;26(8):371-4.
4.Hickey DR, Sangwan S, Bevan JC. Phenytoin-induced resistance to pancuronium. Use of atracurium infusion in management of a neurosurgical patient. Anaesthesia 1988 Sep;43(9):757-9.
5.Ornstein E, Matteo RS, Schwartz AE, Silverberg PA, Young WL, Diaz J. The effect of phenytoin on the magnitude and duration of neuromuscular block following atracurium or vecuronium. Anesthesiology 1987 Aug;67(2):191-6.
6.NORRIS FH Jr, COLELLA J, MCFARLIN D. EFFECT OF DIPHENYLHYDANTOIN ON NEUROMUSCULAR SYNAPSE. Neurology 1964 Sep;14:869-76.
7.Gandhi IC, Jindal MN, Patel VK. Mechaism of neuromuscular blockade with some antiepileptic drugs. Arzneimittelforschung 1976 Feb;26(2):258-61.
8.Soriano SG, Sullivan LJ, Venkatakrishnan K, Greenblatt DJ, Martyn JA. Pharmacokinetics and pharmacodynamics of vecuronium in children receiving phenytoin or carbamazepine for chronic anticonvulsant therapy. Br J Anaesth 2001 Feb;86(2):223-9.
9.Gough JD, Smith A, Wise CC. Phenytoin-induced resistance to vecuronium. Anaesthesia 1989 Jun;44(6):520.
10.Kumar CM, Lawler PG. Phenytoin-induced resistance to vecuronium. Anaesthesia 1989 Mar;44(3):263-4.

See 31 Reviews for this Drug. - OR -

Review this Treatment

Find a Drug:

by name or medical condition or shape/color (Pill Identifier)

(for example: aspirin)

(for example: diabetes)

Report Problems to the Food and Drug Administration
 
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Ask the pharmacist

Questions about medications? Get expert answers by video or live chat about allergies, pregnancy, sleep, and more.
See the Ask the Pharmacist event schedule.

Ask a Question

Popular Slideshows & Tools on WebMD

hands on abdomen
Can you catch one?
Woman sitting in front of UV lights
Is yours working?
woman using breath spray
What's causing yours?
womans hand on abdomen
Are you ready for baby?
MS Overview
Recognizing symptoms.
bowl of yogurt with heart shape
Eat for a healthy heart.
woman doing pushups
To help you get fit.
Colored x-ray of tooth decay
Know what to look for.
Woman sitting with child
Do you know the symptoms?
mosquito
Stings, bites, burns, and more.
Allentown, PA
Are you living in one?
Thyroid exam
See how much you know.

Women's Health Newsletter

Find out what women really need.

WebMD the app

Get trusted health information. Whenever. Wherever... with your iPhone, iPad or Android.

Find Out More

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.