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zidovudine IV

Zidovudine/Probenecid

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not process zidovudine properly.

What might happen:

Your blood levels of zidovudine may increase and cause serious skin rashes or other toxic effects.

What you should do about this interaction:

If you experience any skin rashes, fever, sore throat, increased tiredness, weakness, unusual bleeding or bruising, stomach pains, problems breathing, change in urine color to brown or changes in skin or eye color to yellow, contact your doctor. The dose of your medicines may need to be adjusted.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Kornhauser DM, Petty BG, Hendrix CW, Woods AS, Nerhood LJ, Bartlett JG, Lietman PS. Probenecid and zidovudine metabolism. Lancet 1989 Aug 26; 2(8661):473-5.
2.de Miranda P, Good SS, Yarchoan R, Thomas RV, Blum MR, Myers CE, Broder S. Alteration of zidovudine pharmacokinetics by probenecid in patients with AIDS or AIDS-related complex. Clin Pharmacol Ther 1989 Nov;46(5):494-500.
3.Hedaya MA, Elmquist WF, Sawchuk RJ. Mechanism of zidovudine (AZT) dose-sparing by probenecid in humans. Pharm Res 1989;6(9):S-218.
4.Petty BG, Kornhauser DM, Lietman PS. Zidovudine with probenecid: a warning. Lancet 1990 Apr 28;335(8696):1044-5.
5.Haumont M, Magdalou J, Lafaurie C, Ziegler JM, Siest G, Colin JN. Phenobarbital inducible UDP-glucuronosyltransferase is responsible for glucuronidation of 3'-azido-3'-deoxythymidine: characterization of the enzyme in human and rat liver microsomes. Arch Biochem Biophys 1990 Sep; 281(2):264-70.
6.Hedaya MA, Elmquist WF, Sawchuk RJ. Probenecid inhibits the metabolic and renal clearances of zidovudine (AZT) in human volunteers. Pharm Res 1990 Apr;7(4):411-7.
7.Duckworth AS, Duckworth GW, Henderson G, Contreras G. Zidovudine with probenecid. Lancet 1990 Aug 18;336(8712):441.
8.Sim SM, Back DJ, Breckenridge AM. The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes. Br J Clin Pharmacol 1991 Jul;32(1):17-21.
9.Cretton EM, Schinazi RF, McClure HM, Anderson DC, Sommadossi JP. Pharmacokinetics of 3'-azido-3'-deoxythymidine and its catabolites and interactions with probenecid in rhesus monkeys. Antimicrob Agents Chemother 1991 May;35(5):801-7.

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