Digoxin/Metoclopramide
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Metoclopramide may slow down how quickly your body absorbs your digoxin.
What might happen:
The amount of digoxin in your blood may decrease and it may not work as well. If you stop taking metoclopramide, the amount of digoxin in your blood may increase and cause extra side effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and if you stop taking metoclopramide. Your doctor may want to check the amount of digoxin in your blood and may need to change the dose of your digoxin.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Manninen V, Apajalahti A, Simonen H, Reissell P. Effect of propantheline and metoclopramide on absorption of digoxin. Lancet 1973 May 19; 1(7812):1118-9.
2.Medin S, Nyberg L. Effect of propantheline and metoclopramide on absorption of digoxin. Lancet 1973 Jun 16;1(7816):1393.
3.Fraser EJ, Leach RH, Poston JW, Bold AM, Culank LS, Lipede AB. Dissolution-rates and bioavailability of digoxin tablets. Lancet 1973 Jun 16;1(7816):1393.
4.Thompson WG. Altered absorption of digoxin in patients given propantheline and metoclopramide. Lancet 1973 Apr 7;1(7806):783-4.
5.Lanoxicaps (digoxin solution in capsules) US prescribing information. GlaxoSmithKline October, 2003.
6.Lanoxin (digoxin) Elixir US prescribing information. GlaxoSmithKline September, 2001.
7.Lanoxin (digoxin) Tablets US prescribing information. GlaxoSmithKline February 5, 2010.
8.Manninen V, Apajalahti A, Melin J, Karesoja M. Altered absorption of digoxin in patients given propantheline and metoclopramide. Lancet 1973 Feb 24;1(7800):398-400.
9.Kirch W, Janisch HD, Santos SR, Duhrsen U, Dylewicz P, Ohnhaus EE. Effect of cisapride and metoclopramide on digoxin bioavailability. Eur J Drug Metab Pharmacokinet 1986 Oct-Dec;11(4):249-50.
10.Johnson BF, Bustrack JA, Urbach DR, Hull JH, Marwaha R. Effect of metoclopramide on digoxin absorption from tablets and capsules. Clin Pharmacol Ther 1984 Dec;36(6):724-30.
11.Johnson BF, O'Grady J, Bye C. The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide. Br J Clin Pharmacol 1978 May;5(5):465-7.
