Skip to content
My WebMD Sign In, Sign Up

spironolactone oral


This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Spironolactone may decrease the ability of your kidneys to remove digoxin from your body. It may also interfere with some laboratory tests that measure the amount of digoxin in your blood.

What might happen:

The effects of your digoxin may increase and cause a slow or irregular heartbeat.

What you should do about this interaction:

If you experience a slow or irregular heartbeat, contact your doctor. The dose of your medicine may need adjusting. You may be more likely to experience effects from this interaction if you have liver problems or are elderly. If your doctor orders a blood test to check the amount of digoxin in your blood, remind your doctor and the laboratory that you are taking spironolactone.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


1.Steiness E. Renal tubular secretion of digoxin. Circulation 1974 Jul; 50(1):103-7.
2.Waldorff S, Andersen JD, Heeboll-Nielsen N, Nielsen OG, Moltke E, Sorensen U, Steiness E. Spironolactone-induced changes in digoxin kinetics. Clin Pharmacol Ther 1978 Aug;24(2):162-7.
3.Paladino JA, Davidson KH, McCall BB. Influence of spironolactone on serum digoxin concentration. JAMA 1984 Jan 27;251(4):470-1.
4.Fenster PE, Hager WD, Goodman MM. Digoxin-quinidine-spironolactone interaction. Clin Pharmacol Ther 1984 Jul;36(1):70-3.
5.Waldorff S, Hansen PB, Egeblad H, Berning J, Buch J, Kjaergard H, Steiness E. Interactions between digoxin and potassium-sparing diuretics. Clin Pharmacol Ther 1983 Apr;33(4):418-23.
6.Waldorff S, Berning J, Buch J, Steiness E. Systolic time intervals during spironolactone treatment of digitalized and non-digitalized patients with ischaemic heart disease. Eur J Clin Pharmacol 1982;21(4):269-73.
7.Finnegan TP, Spence JD, Cape RD. Potassium-sparing diuretics: interaction with digoxin in elderly men. J Am Geriatr Soc 1984 Feb;32(2):129-31.
8.Lanoxin (digoxin) Tablets US prescribing information. GlaxoSmithKline August, 2012.

See 317 Reviews for this Drug. - OR -

Review this Treatment

Find a Drug:

by name or medical condition or shape/color (Pill Identifier)

(for example: aspirin)

(for example: diabetes)

Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Ask the pharmacist

Questions about medications? Get expert answers by video or live chat about allergies, pregnancy, sleep, and more.
See the Ask the Pharmacist event schedule.

Ask a Question

Popular Slideshows & Tools on WebMD

hands on abdomen
Can you catch one?
Woman sitting in front of UV lights
Is yours working?
woman using breath spray
What's causing yours?
womans hand on abdomen
Are you ready for baby?
MS Overview
Recognizing symptoms.
bowl of yogurt with heart shape
Eat for a healthy heart.
woman doing pushups
To help you get fit.
Colored x-ray of tooth decay
Know what to look for.
Woman sitting with child
Do you know the symptoms?
Stings, bites, burns, and more.
Allentown, PA
Are you living in one?
Thyroid exam
See how much you know.

Women's Health Newsletter

Find out what women really need.

WebMD the app

Get trusted health information. Whenever. Wherever... with your iPhone, iPad or Android.

Find Out More

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.