Neuromuscular Blocking Agents/Lincosamides
How the interaction occurs:
When these two medicines are taken together, the antibiotic may increase the effects of the nondepolarizing muscle relaxant medicine.
What might happen:
The effects of the nondepolarizing muscle relaxant may last for a longer time and cause severe breathing problems.
What you should do about this interaction:
The nondepolarizing muscle relaxant group of drugs is only used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription and non-prescription medicine, herbal medicines, and nutraceuticals.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Fogdall RP, Miller RD. Prolongation of a pancuronium-induced neuromuscular blockade by clindamycin. Anesthesiology 1974 Oct;41(4):407-8.
2.Booij LH, Miller RD, Crul JF. Neostigmine and 4-aminopyridine antagonism of lincomycin-pancuronium neuromuscular blockade in man. Anesth Analg 1978 May-Jun;57(3):316-21.