Dantrolene/Calcium Channel Blockers
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both medicines affect how your heart uses calcium.
What might happen:
When used to treat or prevent a condition known as malignant hyperthermia, the combination can cause serious and potentially life-threatening affects on the heart.
What you should do about this interaction:
Malignant hyperthermia can be caused by anesthesia and/or surgery. Before any surgery, be sure to let your healthcare professionals (e.g. doctor or pharmacist) know of all the medicines you take.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Goodman-Gilman A. In Gilman AG, Rall TW, Nies AS, Taylor P, editors: Goodman and Gilman's The Phamacological Basis of Therapeutics. 8th edition. Elmsford, New York: Pergamon Press, Inc. 1990.
2.Dantrium (dantrolene sodium) US prescribing information. JHP Pharmaceuticals, LLC. July, 2012.
3.Sennesael J, Lamote J, Violet I, Tasse S, Verbeelen D. Comparison of perindopril and amlodipine in cyclosporine-treated renal allograft recipients. Hypertension 1995 Sep;26(3):436-44.
4.Saltzman LS, Kates RA, Corke BC, Norfleet EA, Heath KR. Hyperkalemia and cardiovascular collapse after verapamil and dantrolene administration in swine. Anesth Analg 1984 May;63(5):473-8.
5.San Juan AC Jr, Wong KC, Port JD. Hyperkalemia after dantrolene and verapamil-dantrolene administration in dogs. Anesth Analg 1988 Aug; 67(8):759-62.
6.Saltzman LS, Kates RA, Norfleet EA, Corke BC, Heath KR. Hemodynamic interactions of diltiazem-dantrolene and nifedipine-dantrolene. Anesthesiology 1984.