Hydrocortisone, Oral/Bile Acid Sequestrants
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, the amount of hydrocortisone absorbed by your body may decrease.
What might happen:
You may experience a decrease in the beneficial effects of hydrocortisone.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, it may be necessary to increase your dose of hydrocortisone or to change the time you take one or both medicines. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Ware AJ, Combes B. Influence of sodium taurocholate, cholestyramine, and mylanta on the intestinal absorption of glucocorticoids in the rat. Gastroenterology 1973 Jun;64(6):1150-5.
2.Johansson C, Adamsson U, Stierner U, Lindsten T. Interaction by cholestyramine on the uptake of hydrocortisone in the gastrointestinal tract. Acta Med Scand 1978;204(6):509-12.
3.Nekl KE, Aron DC. Hydrocortisone-colestipol interaction. Ann Pharmacother 1993 Jul-Aug;27(7-8):980-1.