Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are given together, the beneficial effect of ketamine on your heart and blood system may be decreased.
What might happen:
You may experience a decrease in your blood pressure and slowing of your heartbeat.
What you should do about this interaction:
These two medicines are only used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription medicines, herbal drugs, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Stanley TH. Blood-pressure and pulse-rate responses to ketamine during general anesthesia. Anesthesiology 1973 Dec;39(6):648-9.
2.Johnston RR, Miller RD, Way WL. The interaction of ketamine with d-tubocurarine, pancuronium, and succinylcholine in man. Anesth Analg 1974 Jul-Aug;53(4):496-501.
3.Bidwai AV, Stanley HT, Graves CL, Kawamura R, Sentker CR. The effects of ketamine on cardiovascular dynamics during halothane and enflurane anesthesia. Anesth Analg 1975 Sep-Oct;54(5):588-92.