Vinca Alkaloids/Selected Azole Antifungals
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some azole antifungal medicines may slow down how quickly your liver processes vinca alkaloids.
What might happen:
The levels of vinca alkaloids in your blood may increase and you may experience more chemotherapy-related toxicity than normally expected.
What you should do about this interaction:
Make sure that your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together, or if you have recently (in the past few weeks) undergone chemotherapy with a vinca alkaloid. Your doctor may need to monitor you more closely. Let your doctor know right away if you have any muscle weakness, numbness or loss of feeling, abdominal pain, constipation, seizures, or swelling, or if any side effects are worse than in previous chemotherapy cycles.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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