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Synthroid oral

Digitalis Glycosides/Thyroid; Dextrothyroxine

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known. Your thyroid medicine may decrease the effects of your digoxin.

What might happen:

The effects of your digoxin may decrease and cause shortness of breath or a fast heartbeat.

What you should do about this interaction:

If you experience shortness of breath or a fast heartbeat, contact your doctor. The dose of your medicines may need adjusting.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Frye RL, Braunwald E. Studies on digitalis. III. The influence of triiodothyronine on digitalis requirements. Circulation 1961 Mar; 23:376-82.
2.Doherty JE, Perkins WH. Digoxin metabolism in hypo- and hyperthyroidism. Studies with tritiated digoxin in thyroid disease. Ann Intern Med 1966 Mar;64(3):489-507.
3.Croxson MS, Ibbertson HK. Serum digoxin in patients with thyroid disease. Br Med J 1975 Sep 6;3(5983):566-8.
4.Lawrence JR, Sumner DJ, Kalk WJ, Ratcliffe WA, Whiting B, Gray K, Lindsay M. Digoxin kinetics in patients with thyroid dysfunction. Clin Pharmacol Ther 1977 Jul;22(1):7-13.
5.Huffman DH, Klaassen CD, Hartman CR. Digoxin in hyperthyroidism. Clin Pharmacol Ther 1977 Nov;22(5 Pt 1):533-8.
6.Shenfield GM, Thompson J, Horn DB. Plasma and urinary digoxin in thyroid dysfunction. Eur J Clin Pharmacol 1977 Dec 28;12(6):437-43.
7.Bonelli J, Haydl H, Hruby K, Kaik G. The pharmacokinetics of digoxin in patients with manifest hyperthyroidism and after normalization of thyroid function. Int J Clin Pharmacol Biopharm 1978 Jul;16(7):302-6.

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