Neuromuscular Blocking Agents/Verapamil
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
The cause of the interaction is not known.
What might happen:
The effects of the nondepolarizing muscle relaxant will last for a longer time.
What you should do about this interaction:
The nondepolarizing muscle relaxant group of drugs is only used during surgical procedures or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that all the healthcare professionals are aware of all the different medicines that you are taking. This includes prescription and non-prescription medicine, herbal medicines, and nutraceuticals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.van Poorten JF, Dhasmana KM, Kuypers RS, Erdmann W. Verapamil and reversal of vecuronium neuromuscular blockade. Anesth Analg 1984 Feb;63(2):155-7.
2.Jones RM, Cashman JN, Casson WR, Broadbent MP. Verapamil potentiation of neuromuscular blockade: failure of reversal with neostigmine but prompt reversal with edrophonium. Anesth Analg 1985 Oct;64(10):1021-5.
3.Carlos R, Erill S. Therapeutic rounds: abnormally prolonged responses to neuromuscular blocking agents. Clin Ther 1986;9(1):22-3, 135-6.
4.Wali FA. Interaction of verapamil with d-tubocurarine and cholinergic agonists at the avian neuromuscular junction. Acta Anaesthesiol Scand 1987 Jan;31(1):15-20.