Labetalol/Inhalation Anesthetics
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, the effects of one or both medicines may increase.
What might happen:
An increase in the toxic effects of one or both medicines may occur causing low blood pressure.
What you should do about this interaction:
Inhaled anesthetics are given during surgical operations or in a hospital. If you are to have either inpatient or outpatient surgery, or are to be admitted to the hospital, make sure that your doctor knows all of the medicines that you are taking.Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this drug interaction and may be monitoring you for it. You may need to monitor your blood pressure more frequently while taking these two medicines. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Scott DB, Buckley FP, Drummond GB, Littlewoods DG, Macrae WR. Cardiovascular effects of labetalol during halothane anaesthesia. Br J Clin Pharmacol 1976 Aug;3(4 Suppl 3):817-21.
2.Scott DB, Buckley FP, Littlewood DG, Macrae WR, Arthur GR, Drummond GB. Circulatory effects of labetalol during halothane anaesthesia. Anaesthesia 1978 Feb;33(2):145-56.
3.Hunter JM. Synergism between halothane and labetalol. Anaesthesia 1979 Mar;34(3):257-9.
4.Toivonen J, Virtanen H, Kaukinen S. Deliberate hypotension induced by labetalol with halothane, enflurane or isoflurane for middle-ear surgery. Acta Anaesthesiol Scand 1989 May;33(4):283-9.
