Beta-Blockers/Propafenone
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these medicines are taken together, your body may process your beta-blocker medicine more slowly.
What might happen:
Your blood levels of the beta-blocker medicine may increase and cause abnormally low blood pressure.
What you should do about this interaction:
Contact your doctor if you experience a slowed heartbeat, or dizziness and weakness, especially upon standing.If your doctor prescribes these medicines together, it may be necessary to adjust the dosage of your beta-blocker and monitor your blood pressure more regularly.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Wagner F, Kalusche D, Trenk D, Jahnchen E, Roskamm H. Drug interaction between propafenone and metoprolol. Br J Clin Pharmacol 1987 Aug; 24(2):213-20.
2.Kowey PR, Kirsten EB, Fu CH, Mason WD. Interaction between propranolol and propafenone in healthy volunteers. J Clin Pharmacol 1989 Jun;29(6):512-7.
