Penicillamine/Gold Salts
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both of these medicines can affect your kidneys and the cells in your bone marrow that produce blood cells.
What might happen:
If you take these medicines together, you may be at a higher risk of developing problems with your kidneys or blood.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to run some blood tests to check your blood and your kidney function. Let your healthcare professionals know if you have any side effects from your medicines.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
References:
1.Cuprimine (penicillamine) US prescribing information. Merck & Co., Inc. October, 2004.
2.Solganal (aurothioglucose) US prescribing information. Schering-Plough Corporation March, 1996.
3.Aaron S, Davis P, Biggs D. D-penicillamine does not chelate gold. J Rheumatol 1984 Dec;11(6):869-70.
4.Kean W, Lock CJ. Penicillamine does not chelate gold (I). J Rheumatol 1983 Aug;10(4):527-30.
5.Davis P, Barraclough D. Interaction of D-penicillamine with gold salts: in vivo studies on gold chelation and in vitro studies on protein binding. Arthritis Rheum 1977 Sep-Oct;20(7):1413-8.
