Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Saquinavir may inhibit the metabolism of your antiarrhythmic.
What might happen:
The amount of antiarrhythmic in your blood may increase and cause life-threatening changes to your heart rate.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) right away about taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Invirase (saquinavir mesylate) US prescribing information. Roche Laboratories, Inc. February, 2012.
2.Fortovase (saquinavir) US prescribing information. Roche Laboratories, Inc. December, 2004.
3.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.